- Ebola virus disease is a rare, severe infection found in several countries throughout sub-Saharan Africa.
- It can be transmitted through direct skin or mucous membrane contact with blood or body fluids of infected patients or corpses, or through the placenta.
- Risk is low for general travelers.
- Symptoms include fever, headache, muscle aches, sore throat, general discomfort, abdominal pain, diarrhea, vomiting, and hemorrhage, in some cases.
- Death or recovery from the illness may occur; symptoms gradually resolved in 7-21 days for survivors.
- Personal protection measures are the main prevention strategy.
Ebola virus disease (EVD) is a rare, severe infection found in several countries throughout sub-Saharan Africa. Initial symptoms of EVD are nonspecific and similar to other more common diseases such as malaria.
EVD infection is rare, despite sporadic outbreaks in several African countries. Since the late 1970s, outbreaks have been reported in rural areas of Gabon, Democratic Republic of the Congo, South Sudan, Uganda, and Angola. From March 2014 until mid-2016 30,000 cases occurred in Guinea, Liberia, and Guinea; no transmission has occurred since.
Human-to-human transmission occurs through direct skin or mucous membrane contact with blood or body fluids (including sweat, urine, semen, and breast milk) of acutely ill EVD patients or infected deceased persons (through burial practices) or through the placenta. Persons infected with EVD are not infectious to others until symptom begin. After death, live virus remains for as long as 7 days on body surfaces, mucosa, and blood and for 3 days in tissues. Transmission also occurs through contact with or consumption of bush meat, contact with infected non-human primates, and bats.
Infectious virus has also been found in body fluids such as in the womb of pregnant women, brain, spinal cord, and eyes. Dead Ebola virus breakdown products have been detected in vaginal and rectal swabs. The virus can persist in semen for more than 18 months. There is evidence of sexual transmission 6 months after recovery in 1 case in Liberia. Masturbation (through contamination of surfaces) is a possible risk.
Patterns of transmission are inconsistent with airborne transmission.
- Risk is low for general travelers and business travelers.
- Risk is similarly low for persons visiting friends and relatives, unless the traveler has direct physical contact with infected fluids from corpses, sick persons, or sick animals during an epidemic.
- Risk is low for persons with direct contact with body fluids of recovered patients.
- Risk is high for health care workers (HCWs) and volunteers, especially those involved in caring for EVD patients. Implementation of recommended precautions reduces risk, although infections have occurred despite stringent precautions, including modern personal protective gear.
The incubation period is 2-21 days (average of 10 days). Symptoms usually begin abruptly with high fever, headache, muscle aches, sore throat, and general discomfort. Abdominal pain, cramps, diarrhea, and vomiting develop on the third day and, in some cases, external and internal bleeding may begin on the fifth day, leading rapidly to shock and death. Survivors show gradual resolution of symptoms within 7-12 days.
Although several candidate vaccines are currently at different stages of development, no clinically proven vaccine is currently available to travelers. No antivirals for self-treatment are available. Therefore, personal protection measures are the main prevention strategy.
In addition, if traveling to affected countries:
- Use alcohol-based hand sanitizers for hand hygiene in health care settings (when hands are not visibly soiled with dirt, blood, or other body fluids). If alcohol-based hand sanitizers or soap and water are unavailable, use of a 0.05% chlorine solution applied for a minimum time of 40-60 seconds until hands are dried is appropriate and likely to be efficacious.
- Avoid direct contact with corpses, people with currently or recently diagnosed EVD, non-human primates, bats (and caves and other places where bats congregate), and health care environments that may have become contaminated.
- Avoid consumption of bush meats.
- Condom use during sexual activity is recommended.
- Ebola virus is susceptible to most common disinfectants and alcohol-based products (e.g., hand sanitizers) and can be inactivated by heating for 30-60 minutes at 60°C (140°F) or by boiling for 5 minutes.
HCWs are at high risk when actively involved in an outbreak. Strict adherence to stringent procedures as defined by U.S. CDC is necessary. Specialized personal protection equipment is unlikely to be found in standard hospitals throughout Africa.
Need for Medical Assistance
All cases of suspected EVD should receive prompt medical care in a specialized infectious disease unit, as accurate diagnosis requires specialized laboratory facilities, and supportive care is complex.
EVD should be considered in any traveler with an abrupt onset of fever or extreme malaise within 2-21 days of return from affected areas.
Persons with unrelated medical problems who are traveling or residing in areas undergoing a known EVD outbreak may not be accepted by hospitals in Europe or in countries elsewhere to which they would normally be evacuated.